What is “Energizing the Egg” in Reproductive Medicine?

After the discovery of the IVF technology in 1978, a continuous evaluation has continued to improve the outcome of this technology. “Energizing the Egg” is also a development in this field to improve the outcome of the IVF treatment. Jonathan Tilly is the developer of a breakthrough technology that can rejuvenate the women’s oocytes by using oocyte precursor cells and helps infertile women to conceive. This technology is specifically useful for women who unable to conceive even after the IVF treatment due to poor quality embryo formed during in-vitro fertilization.

Energizing the Egg: infertility treatment

Jonathan Tilly is a researcher at Harvard Medical School and Massachusetts General Hospital. In the journal Nature, the promising technology developed by Tilly was first published. Tilly conducted animal research through which he had found that the egg precursor cells in the ovaries of adult mice were capable to generate new eggs.

Conduction of consequent human trials established that women also have a similar type of precursor cells, which can convert to mature fresh young eggs by harvesting through an ovarian biopsy. This advanced technological development facilitates clinicians to utilize oocyte precursor cells to rejuvenate eggs of the infertile patients who unable to conceive due to egg-related issues.

“Energizing the Egg” technology is used to form new eggs by utilizing immature egg cells in ovarian tissue or to rejuvenate existing eggs of infertile women. This technology increases the scope of conception for older women.  

Clinical utilization of “Energizing the Egg” technology

Co-founder of OvaScience Michelle Dipp has the vision to use this novel “Energizing the Egg” technology and subsequent research findings for treating women who strive to have their biological children. The OvaScience team provided the effort to turn this basic science into clinical practice.  

In the clinical practice, clinical researchers use precursor cells to obtain autologous mitochondria and then the collected mitochondria injected into the oocytes at the time of sperm injection.    

Evidential support of the success of utilizing this “Energizing the Egg” technology (OvaScience)

The successful utilization of this technology provided the first “OvaScience baby” in 2015. Journal published article also reported the accumulated result of two IVF centers, one in Toronto, Canada and the in Dubai, UAE showed 26% and 18% clinical pregnancy rate by attempting OvaScience’s AUGMENT technology in the infertility treatment procedure. Moreover, the embryo transmission rates were 46% and 38% respectfully in the two centers by utilizing this technology.  

Also, in this issue of this journal, there is a paper by Fakih et al. reporting accumulated results from two IVF centers, one in Toronto, Canada, headed by Robert Casper, MD, and the Overall result of these two IVF centers reported that the 93 patients included in this research from these two centers, who received 328 IVF treatment cycles before the AUGMENT treatment. Inclusion of the AUGMENT technology in both the clinical centers provided a marked improvement in IVF success rates, ongoing clinical pregnancy rate. A 3 and 6 fold enhancement in the clinical pregnancy rate was observed in IVF treatment and an 11- and 18- fold increase in ongoing clinical pregnancy rates per initiated cycle, respectively. Comparison between the AUGMENT treatment group and the ICSI-only group also reported the higher rate of embryo transfer in the AUGMENT treatment group than in the ICSI-only group.

Current clinical utilization of OvaScience

Clinical scientist reported that the cytoplasmic mitochondria are the main source of energy for fertilization and early embryo development and OvaScience technology use this current finding. It has already established that the mitochondrial number declination and reduction of functional ability of mitochondria have a direct negative impact on the fertilization efficacy of the women’s egg and pregnancy rates. Years back, Jacques Cohen, a researcher had already tried to improve oocyte reproductive performance by initiating the cytoplasm exchange into potentially compromised recipient-patient oocytes in an attempt to add mitochondria to the “older” oocyte. But this process had abandoned as it involved heteroplasmy (a three-parent pregnancy) and raised a question about potential safety concerns.  

But this issue is not allowable in the OvaScience treatment because an autologous source is used in this technology instead of using third-party mitochondria. An egg precursor cells derived autologous mitochondrial injection energizes the oocyte by utilizing OvaScience technology. However, ongoing research will provide more information about this technology.    

Reference:

https://www.longdom.org/open-access/after-37-years-whats-in-the-store-for-ivf-a-look-ahead-on-the-trends-and-developments-that-are-shaping-the-future-of-reproductive-medicine-2375-4508-1000e116.pdf

Leave a Reply

Your email address will not be published. Required fields are marked *