Can genetic test be a solution to pursue IVF successfully in Endometriosis

Endometrial-like tissue development and progression at the exterior of the uterus often causing the chronic inflammatory condition and subsequent adhesions and scar tissue deform the pelvic anatomy of the affected women. Almost 6 to 8 percents of women globally diagnosed with endometriosis every year.

Besides other symptoms, 30 to 50 percent of women with endometriosis having an infertility problem.

The usual monthly fertility range in normal, healthy couples lies in between 0.15 to 0.20, which can decrease with increasing age.

But endometriosis affected women have significantly lowered fertility range than the normal fertile women.

Experts provided the estimated infertility range is in between 0.02 to 0.1/ month in women with endometriosis and that increases the scope of infertility almost  6 to 8 times greater than the healthy women.

Along with pelvic anatomical distortion, hormonal disorder and peritoneal malfunctioning lead to ovulatory disorders.  Activation of ovum capture inhibitor in endometriosis decreases detainment of ovum.

In addition, faulty uterine contractility in endometriosis also a major cause of defective menstruation cycle, obstructed gametes transportation, abortive conception, faulty implantation, and failure to continue gestation period successfully.

It has been also found that women with endometriosis have a risk of a decreased number of oocytes and poor embryo quality. Implantation and receptivity disorders are common in endometriosis.

In-vitro fertilization is an assistive reproductive technique provide a possibility to resolve the infertility issue. Many women with endometriosis are nowadays opting IVF process to have their own baby.  But unfortunately, the success rate is lower than the expected due to an increased rate of miscarriage.

One of the common problems of IVF treatment failure in endometriosis is chromosomal abnormalities, which causes failure of embryo implantation.

The failure of the IVF process is considered a massive heartbreaking incident for the couple. The whole IVF process is an expensive and time-consuming event.  Therefore, failure of the IVF process is also a huge loss of money and in-vein utilization of time.

Continuous advancement in genetic screening tests is evident.  Pre-implantation genetic screening process thought to be a corrective measure to establish a successful IVF process.  This genetic screening conducted for detecting the numerical chromosomal abnormalities in embryos to get better implantation rate subsequent to IVF.

Cleavage stage biopsy is one of the most common processes conducted for genetic screening to ensure the aneuploidy (instead of 46 chromosomal number, the embryo may have 45 or 47).

However, recently blastocyst biopsy is a more preferable method to conduct genetic screening. In this process, the scope of genotype difference in the single fertilized egg is lesser (decrease mosaicism) and amount of DNA is sufficient to perform test efficiently.

Experts also suggested array comparative genomic hybridization or single nucleotide polymorphism microarray can also be performed to get better test report instead of using fluorescent in situ hybridization with 9 to 12 chromosome.

High-quality embryo culture is an utmost need to get an accurate result of genetic testing. Technically competent staff is another critical requirement to perform the genetic test correctly.

High-quality embryo culture can be established by extending embryo culture towards day 5/6 with sufficient medical confirmation.

Routine competence assessments require to perform to check the competence of clinical staff. But still, the medical research unit expecting more precise clinical research data to evaluate the efficacy of genetic testing, as the success of the IVF technique to treat the infertility issue in endometriosis.

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