Can genetic test be a solution to pursue IVF successfully in Endometriosis

Endometrial-like tissue development and progression at the exterior of the uterus often cause the chronic inflammatory condition and subsequent adhesions and scar tissue deform the pelvic anatomy of the affected women.

Almost 6 to 8 percent of women globally are diagnosed with endometriosis every year.

Besides other symptoms, 30 to 50 percent of women with endometriosis have an infertility problem.

The usual monthly fertility range in normal, healthy couples lies between 0.15 to 0.20, which can decrease with increasing age.

But endometriosis affected women have a significantly lowered fertility range than normal fertile women.

Experts provided the estimated infertility range is between 0.02 to 0.1/ month in women with endometriosis and that increases the scope of infertility almost  6 to 8 times greater than the healthy women.

Along with pelvic anatomical distortion, hormonal disorders, and peritoneal malfunctioning lead to ovulatory disorders. 

Activation of ovum capture inhibitor in endometriosis decreases the detainment of ovum.

Besides, faulty uterine contractility in endometriosis is also a major cause of defective menstruation cycle, obstructed gametes transportation, abortive conception, faulty implantation, and failure to continue the gestation period successfully.

It has been also found that women with endometriosis have a risk of a decreased number of oocytes and poor embryo quality.

Implantation and receptivity disorders are common in endometriosis.

In-vitro fertilization is an assisted reproductive technique that provides a possibility to resolve the infertility issue.

Many women with endometriosis are nowadays opting IVF process to have their babies. 

But unfortunately, the success rate is lower than expected due to an increased rate of miscarriage.

One of the common problems of IVF treatment failure in endometriosis is chromosomal abnormalities, which cause the failure of embryo implantation.

The failure of the IVF process is considered a massive heartbreaking incident for the couple.

The whole IVF process is an expensive and time-consuming event. 

Therefore, failure of the IVF process is also a huge loss of money and utilization of time.

Continuous advancement in genetic screening tests is evident. 

The pre-implantation genetic screening process is thought to be a corrective measure to establish a successful IVF process. 

This genetic screening was conducted to detect the numerical chromosomal abnormalities in embryos to get a better implantation rate after IVF.

Cleavage-stage biopsy is one of the most common processes conducted for genetic screening to ensure aneuploidy (instead of 46 chromosomal numbers, the embryo may have 45 or 47).

However, recently blastocyst biopsy is a more preferable method to conduct genetic screening.

In this process, the scope of genotype difference in the single fertilized egg is lesser (decrease mosaicism) and the amount of DNA is sufficient to perform tests efficiently.

Experts also suggested array comparative genomic hybridization or single nucleotide polymorphism microarray can also be performed to get better test reports instead of using fluorescent in situ hybridization with 9 to 12 chromosomes.

High-quality embryo culture is an utmost need to get an accurate result of genetic testing.

Technically competent staff is another critical requirement to perform the genetic test correctly.

High-quality embryo culture can be established by extending embryo culture towards day 5/6 with sufficient medical confirmation.

Routine competence assessments are required to be performed to check the competence of clinical staff.

But still, the medical research unit expects more precise clinical research data to evaluate the efficacy of genetic testing, as the success of the IVF technique to treat the infertility issue in endometriosis.

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