Egg Donation Abroad: Exploring International Options and Regulations

Egg donation has become an increasingly popular option for individuals or couples struggling with infertility. However, in some countries, the demand for donor eggs far exceeds the supply, leading many to explore international options. While seeking egg donation abroad can provide hope for starting a family, it’s crucial to understand the various international regulations and considerations Read more about Egg Donation Abroad: Exploring International Options and Regulations[…]

egg donation requirement for pregnancy and parent hood

Online egg donor recruitment

Female infertility can be treated with various treatment options. Assisted reproductive technology including IVF procedures is a very common infertility treatment. For infertile women who cannot conceive through their egg then advanced ART technology provides the option to use a donor egg to experience parenthood. Currently, the demand for egg donors is increasing significantly to Read more about Online egg donor recruitment[…]

Egg snow

What are the drawbacks of freezing eggs or sperms for future parenting?

Freezing surplus eggs and sperm for future use is a common technique used in the assisted reproductive system.

Egg snow

But some concerns need to consider of application of frozen eggs or frozen sperm for future parenting. 

Method related drawbacks

Slow freezing and vitrification are two cryopreservation techniques commonly used for egg and sperm freezing.

Currently, human sperm are cryopreserved by applying a slow freezing process, while vitrification is applied for oocytes.

Furthermore, Open Pulled Straw and Closed Pulled Straw are two vitrification systems widely used for gametes and embryos.

However, the application of the open or close method is a debatable discussion.

Some experts believe that the open system provides a better result with an acceptable contamination risk.

But some experts stated that no difference in result for both the system and the closed system is significantly safer than the open system.

Therefore, both these methods have some conflicting results.

Liquid nitrogen is widely used as a cryogenic fluid because of its ability to maintain the ultralow temperature of −196°C that is quite low than water freezing.

At this temperature, physical and chemical reactions slow down and stop the degradation of the preserved material.

But using liquid nitrogen has some drawbacks.

Many microorganisms are able to survive in cryogenic temperatures found in liquid nitrogen and many are the factors that contribute to increasing their resistance to low temperatures.

This increases the scope of cross-contamination through the transmission of pathogens between cryopreserved cell samples during storage in liquid nitrogen.

Cross-contamination is considered a potential risk in assisted reproduction techniques.

Hepatitis B virus (HBV), herpes simplex, adenovirus, and papillomavirus are some viral pathogens that can cross-contaminate the cryopreserved gametes through liquid nitrogen.

Experts are also concerned about Zika virus transmission that may be present in frozen semen for a long period and cause teratogenicity, though no study confirms this finding.

Researchers reported that LN2 vapor is a safer alternative option to liquid nitrogen for storing cryopreserved samples.

Physiological drawbacks 

The scope of cell destruction during freezing and thawing due to intracellular ice crystals formation is one of the primary drawbacks of cryopreservation of gametes.

To solve this problem, some steps are taken care of that are as follows:

  • The total solute concentration with different cryoprotectants is increasing
  • The degree of cellular dehydration is increasing
  • The speed of cooling and/or warming is changing
  • Intracellular ice crystal formation can also be solved by shifting water out of a cell.

But osmotic shock develops due to the application of cryoprotectants forces the movement of the water by osmosis and leads to dehydration of the cell that causes a detrimental change in cell volume. 

Fluctuation of physical and chemical factors during the egg or sperm freezing process has a potential impact on the DNA structure of the cell.

For instance, alteration of osmotic pressure during the freezing process causes chromosome aberrations or elevations in sister chromatid exchange frequencies in hamster ovary cells and lymphocytes.

Thus, hyperosmotic pressure may cause DNA damage or hinder DNA repair leading to chromosomal aberrations.

Freezing impacts on eggs quality 

Progressive loss of bipolar spindle structure coexisting with chromosome displacement is resultant of leaving oocytes for longer than optimum time.

Egg freezing and/or pre-freezing influences alteration either in DNA structure or egg components implicated in repair mechanisms.

Many research studies found that cryopreservation leads to DNA fragmentation.

However, the same method does not apply for egg quality assessment after cryopreservation. Therefore, it is difficult to state that a clear conclusion.  

Freezing impacts on sperm quality 

Some research findings reported that the freezing technique modifies the DNA integrity of human sperm.

Glycerol is a primary cryoprotectant used for commercial purposes.


characteristics in the baby born through Egg donors

Whose characteristics are inherited in the baby born using donor eggs?

A better understanding of uterine physiology and embryo provides the scope for steady improvement in the field of assisted reproductive technology (ART) and achieves a  significant success rate. The number of donor egg recipients is increasing day by day as the childbearing age of a woman is postponed due to multiple social reasons. But it Read more about Whose characteristics are inherited in the baby born using donor eggs?[…]

receiving egg donation preparation

What are the preparations required for receiving egg donation?

Finding of any abnormality after testing all the necessary biomarkers require for normal conceiving, which cannot be rectified by available treatment measures, then an expert OB-GYN (obstetrician-gynecologist) can refer an infertile female for proceeding with donor egg and/or surrogacy to build their family. But before starting the clinical procedure, a certain time requires to complete Read more about What are the preparations required for receiving egg donation?[…]

Egg Sharing

Is Joining egg sharing program lower the scope of Pregnancy?

Is sharing egg impact egg supply? Women with bellow 35 years of age produce surplus eggs can share with other women who unable to produce eggs in their ovary.  But may one query restrict potential egg donor to share her egg with others, i.e. is sharing egg harmful for future pregnancy of the egg donor? Read more about Is Joining egg sharing program lower the scope of Pregnancy?[…]

donor egg IVF after 40 : Pic Easter egg

How IVF with donor eggs will help you to become a mother after 40?

Being a mother is a boon for every woman – as motherhood is a beautiful feeling that every woman wants to experience. In today’s environment and culture most of the women are not able to experience this wonderful feeling due to various reasons mainly as most of them are working which leads to late marriages. Read more about How IVF with donor eggs will help you to become a mother after 40?[…]

Questions that Egg Donors Should Ask

Field of fertility treatment has witnessed a huge and significant growth in last couple of years, especially with increasing interest among couples and intended parents who wants to have their child through any healthy and certain medical procedure. Now, it has become a trend to freeze eggs at the young age of 20 to 25 Read more about Questions that Egg Donors Should Ask[…]

egg donation services in Georgia

Things to Consider while Selecting Egg Donation Services in Georgia

Egg donation is a little complex process, where the donor donates her healthy egg to a couple who is infertile and due to that, they cannot conceive. A woman who donates her egg is known as an egg donor or surrogate. Some various services and agencies offer egg donation process to these couple in Georgia. Read more about Things to Consider while Selecting Egg Donation Services in Georgia[…]

easter egg (img): donor eggs georgia: Egg Donation Services in Georgia

Donor Eggs for parenting in Georgia

ARTbaby Surrogacy center operates a comprehensive egg donation to women who are unable to produce eggs or can’t use their own eggs, the chance to become pregnant and have children. It assists infertile women and couples to have a family – something they are unable to achieve on their own. We offer in-depth information regarding Read more about Donor Eggs for parenting in Georgia[…]